Quantitative and qualitative assessment of a pituitary neuroendocrine tumor's T2-signal intensity in acromegaly - a call for unification.

ABSTRACT:

Introduction

The T2-signal intensity (SI) of somatotroph pituitary neuroendocrine tumors (sPitNET) is associated with treatment response and granulation pattern. Our aim was to evaluate SI assessment methods and their clinical implications, including responsiveness to preoperative first-generation somatostatin analogs (SSA).

Methods

This single-center, observational study included unselected, consecutive patients with newly diagnosed acromegaly. Out of 109 treatment-naïve patients, 69 were eligible. The qualitative Visual Method involved a visual comparison of the sPitNET with the temporal gray matter. The Three Tissue Method compared the quantified SI of the sPitNET, temporal white matter, and gray matter. The signal intensity ratio of the sPitNET vs. gray matter (GM-SIR) w

SUBMITTER: Godlewska-Nowak M 

PROVIDER: S-EPMC11618535 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature