Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety.

ABSTRACT: Depression-anxiety comorbidity is commonly attributed to the occurrence of specific symptoms bridging the two disorders. However, the significant heterogeneity of most bridging symptoms presents challenges for psychopathological interpretation and clinical applicability. Here, we conceptually established a common bridging factor (cb factor) to characterize a general structure of these bridging symptoms, analogous to the general psychopathological p factor. We identified a cb factor from 12 bridging symptoms in depression-anxiety comorbidity network. Moreover, this cb factor could be predicted using edge-centric connectomes with robust generalizability, and was characterized by connectome patterns in attention and frontoparietal networks. In an independent twin cohort, we found that these p

SUBMITTER: Chen Z 

PROVIDER: S-EPMC11618586 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature