Transthyretin Tetramer Destabilization and Increased Mortality in the General Population.

ABSTRACT:

Importance

Transthyretin tetramer destabilization is the rate-limiting step in the development of transthyretin cardiac amyloidosis, an underrecognized contributor to mortality in older adults.

Objective

To test the hypothesis that transthyretin tetramer destabilization is associated with all-cause and cardiovascular mortality in the general population.

Design, setting, and participants

In this cohort study including individuals aged 20 to 80 years, genetic data were analyzed from 2 similar prospective studies of the Danish general population, the Copenhagen City Heart Study (CCHS) and the Copenhagen General Population Study (CGPS). Observational data from a subsample of the same studies where transthyretin was measured consecutively were also analyzed. In both studie

SUBMITTER: Christoffersen M 

PROVIDER: S-EPMC11618624 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature