Capturing the Full Range of Buprenorphine Treatment Response.

ABSTRACT:

Importance

Reliance on abstinence-based treatment success rules may fail to capture the full continuum of treatment response to buprenorphine plus medical counseling (BUP+MC) for opioid use disorder (OUD).

Objective

To describe patterns of reduction in illicit opioid use of patients both labeled as a success and nonsuccess based on an abstinent-based treatment outcome rule.

Design, setting, and participants

This study is a secondary data analysis of 4 harmonized randomized clinical trials on BUP+MC for OUD from multiple sites that included 869 patients with OUD. These data were analyzed on April 23, 2024. By week 12, 643 participants of the sample original remained (74%).

Intervention

All studies included patients randomized to BUP+MC or BUP plus enhanced MC (e

SUBMITTER: Bailey AJ 

PROVIDER: S-EPMC11618630 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature