Contributions of prenatal risk factors and neonatal epigenetics to cognitive outcome in children born very preterm.

ABSTRACT: Children born less than 30 weeks gestational age (GA) are at high risk for neurodevelopmental delay compared to term peers. Prenatal risk factors and neonatal epigenetics could help identify preterm children at highest risk for poor cognitive outcomes. We aimed to understand the associations among cumulative prenatal risk, neonatal DNA methylation, and child cognitive ability at age 3 years, including whether DNA methylation mediates the association between prenatal risk and cognitive ability. We studied 379 neonates (54% male) born less than 30 weeks GA who had DNA methylation measured at neonatal intensive care unit discharge along with 3-year follow-up data. Cumulative prenatal risk was calculated from 24 risk factors obtained from maternal report and medical record and epigenome-wide n

SUBMITTER: Camerota M 

PROVIDER: S-EPMC11618652 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature