Sofosbuvir Polymorphs Distinguished by Linearly and Circularly Polarized Raman Microscopy.

ABSTRACT: Most currently marketed pharmaceuticals are manufactured in the solid state, where the bioavailability of the active pharmaceutical ingredient (API) can be optimized through different polymorphs, cocrystals, solvates, or salts. Efficient techniques are needed to monitor the structure of pharmaceuticals during production. Here, we explore the potential of linearly and circularly polarized Raman microscopy for distinguishing three polymorphs of sofosbuvir, an antiviral drug used to treat hepatitis C. Raman spectra were recorded on a Raman microscope for a polycrystalline API diluted in a KBr matrix. To understand spectral features including the low-frequency region, we simulated band frequencies and intensities using quantum-chemical computational strategies based on cluster and transfer app

SUBMITTER: Schrenkova V 

PROVIDER: S-EPMC11618743 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature