Rapid effects of valproic acid on the fetal brain transcriptome: implications for brain development and autism.

ABSTRACT: There is an increased incidence of autism among the children of women who take the anti-epileptic, mood-stabilizing drug, valproic acid (VPA) during pregnancy; moreover, exposure to VPA in utero causes autistic-like symptoms in rodents and non-human primates. Analysis of RNA-seq data obtained from E12.5 fetal mouse brains 3 hours after VPA administration to the pregnant dam revealed that VPA rapidly and significantly increased or decreased the expression of approximately 7,300 genes. No significant sex differences in VPA-induced gene expression were observed. Expression of 399 autism risk genes was significantly altered by VPA as was expression of 258 genes that have been reported to modulate fetal brain development but are not otherwise linked to autism. Expression of genes associated wit

SUBMITTER: Dorsey SG 

PROVIDER: S-EPMC11618798 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature