Exploring the Role of Preoperative Systemic Therapy and Primary Resection in NSCLC With Extrathoracic Metastases: Identifying the Optimal Candidates.

ABSTRACT:

Background

In non-small cell lung cancer (NSCLC), patients with extrathoracic metastases typically have a poor prognosis, with systemic chemotherapy being the standard care. The full potential of primary resection therapy (PRT) in these patients, especially during the immunotherapy era, is not fully established. Additionally, the effectiveness of systemic preoperative therapy in this context is unclear.

Methods

This retrospective study identified NSCLC patients with extrathoracic metastases from the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2019. We compared the survival rates of those treated with just chemotherapy vs those receiving both chemotherapy and PRT.

Results

In a study of 41 909 patients with extrathoracic metastatic NSCLC rec

SUBMITTER: Jin X 

PROVIDER: S-EPMC11618963 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature