Association between lactulose administration and hypercalcemia in dogs medically managed for hepatic encephalopathy.

ABSTRACT:

Objectives

Identify if lactulose administration is associated with hypercalcemia in dogs medically managed for hepatic encephalopathy due to a portosystemic shunt and measure any magnitude in change of ionized calcium (iCa) or total calcium.

Animals

Seventeen client-owned dogs diagnosed with a portosystemic shunt and medically managed with lactulose.

Procedure

Total calcium and iCa were measured at Time point 1 (T1), before starting medical management; and Time point 2 (T2), the time of a reassessment after > 3 wk of lactulose administration.

Results

There were no statistically significant differences in iCa or total calcium between T1 and T2. Lactulose dose was positively correlated with change in iCa between T1 and T2.

Conclusion and clinical relevance

SUBMITTER: Hawes CE 

PROVIDER: S-EPMC11618998 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature