Risk factors for mortality in patients with sepsis on extracorporeal membrane oxygenation and/or continuous renal replacement therapy: a retrospective cohort study based on MIMIC-IV database.

ABSTRACT:

Objective

This study aimed to identify risk factors for mortality in septic patients undergoing extracorporeal membrane oxygenation (ECMO) and/or continuous renal replacement therapy (CRRT).

Methods

Data from the MIMIC-IV database were retrospectively reviewed for 24,502 septic patients treated with ECMO or CRRT between 2008 and 2019. After applying inclusion and exclusion criteria, 70 patients receiving ECMO, 513 receiving CRRT, and 22 receiving both were included in the final analysis. Univariate and multivariate stepwise Cox regression analyses were performed to identify independent risk factors for mortality. Model performance was assessed using receiver operating characteristic (ROC) curve analysis. We also provided model-agnostic explanations for each Cox regression mo

SUBMITTER: Chu T 

PROVIDER: S-EPMC11619025 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature