Typhoid & paratyphoid vaccine development in the laboratory: a review & in-country experience.

ABSTRACT: Enteric fever is caused by the infection of Gram-negative bacteria, Salmonella enterica serovar Typhi and Salmonella enterica serovar Paratyphi (S. Paratyphi) A, B and C, through contaminated food and water. The disease almost exclusively affects the populations living in low- and middle-income countries, with the World Health Organization Southeast Asian Region (WHO SEAR) having the highest endemicity. Despite humans being the sole reservoir of infection and antibiotics and vaccines are made available, the disease was not taken up for elimination until recently due to several biological and technical reasons, including the lack of accurate and region-specific disease surveillance data in the real-time diagnostic inaccuracy of acute infections, difficulty in identifying the chronic asympto

SUBMITTER: Chakraborty S 

PROVIDER: S-EPMC11619049 | biostudies-literature | 2024 Sep&Oct

REPOSITORIES: biostudies-literature