Identification of potential drug targets for diabetic polyneuropathy through Mendelian randomization analysis.

ABSTRACT:

Background

Diabetic polyneuropathy (DPN) is a common diabetes complication with limited treatment options. We aimed to identify circulating plasma proteins as potential therapeutic targets for DPN using Mendelian Randomization (MR).

Methods

The protein quantitative trait loci (pQTLs) utilized in this study were derived from seven previously published genome-wide association studies (GWASs) on plasma proteomics. The DPN data were obtained from the IEU OpenGWAS project. This study employed two-sample MR using MR-Egger and inverse-variance weighted methods to evaluate the causal relationship between plasma proteins and DPN risk, with Cochran's Q test, and I² statistics, among other methods, used to validate the robustness of the results.

Results

Using cis-pQTL

SUBMITTER: Chen X 

PROVIDER: S-EPMC11619124 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature