Esketamine and neurocognitive disorders in adult surgical patients: a meta-analysis.

ABSTRACT:

Background

Prior meta-analyses have established the potential of intravenous ketamine in safeguarding against neurocognitive impairment, but the efficacy of intravenous esketamine for the prevention of perioperative neurocognitive disorders (PND) remains uncertain. The primary aim of this meta-analysis was to conduct a comprehensive evaluation of the effects of esketamine on PND in adult surgical patients undergoing general anesthesia.

Methods

We searched several electronic databases and clinical trial registries to find relevant trials. Randomized controlled trials of perioperative use of esketamine adjuvant were included in the analysis. The main outcome measured was the risk of postoperative delirium(POD) and postoperative cognitive dysfunction (POCD). Secondary outcomes

SUBMITTER: Lin X 

PROVIDER: S-EPMC11619128 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature