Revisiting the follicle-stimulation hormone receptor expression and function in human myometrium and adipose tissue.

ABSTRACT:

Background

Extragonadal follicle-stimulating hormone receptor (FSHR) expression at low levels has been shown in several normal and tumor tissues, including myometrium and adipose tissue. FSH-FSHR signaling in the myometrium has been suggested to regulate uterine contractile activity and the timing of labor. In contrast, FSH-FSHR has been linked to the activation of brown/beige fat thermogenesis in adipose tissue. The issue of extragonadal FSHR expression and its functionality remains contentious within the scientific community, as contradictory findings necessitate further independent and critical analyses. Hereby, we re-investigated the FSHR expression and its functionality in normal non-pregnant (M-NP) and pregnant (N-P) human myometrium, as well as in human visceral (VAT) and su

SUBMITTER: Palak E 

PROVIDER: S-EPMC11619181 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature