T follicular helper cell is essential for M2 macrophage polarization and pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension.

ABSTRACT:

Background

Hypoxia-induced pulmonary hypertension (HPH) is a subgroup of type 3 pulmonary hypertension that may cause early right ventricular failure and eventual cardiac failure, which lacks potential therapeutic targets. Our previous research demonstrated that T follicular helper (T_FH) cells that produce IL-21 were involved in HPH. However, the molecular mechanisms of T_FH/IL-21-mediated pathogenesis of HPH have been elusive. Here we investigate the role of T_FH cells and IL-21 in HPH.

Methods

Studies were performed in C57BL/6 mice or IL-21 knockout mice exposed to chronic hypoxia to induce PH, and examined by hemodynamics. Molecular and cellular studies were performed in mouse lung and pulmonary arterial smooth muscle cells (PASMCs). M2 sign

SUBMITTER: Li C 

PROVIDER: S-EPMC11619207 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature