<i>bla</i>_GES-producing ST654 comprises a quarter of all carbapenem-resistant <i>Pseudomonas aeruginosa</i> in blood isolates from 15 hospitals.

ABSTRACT: Carbapenem-resistant Pseudomonas aeruginosa (CRPA) are of major clinical concern. We analyzed 85 P. aeruginosa blood isolates non-susceptible to carbapenems collected during 2021-2023 from 15 medical centers in Israel. We aimed to determine the prevalence of high-risk clones, examine clonality, test antibiotic susceptibility, and assess the presence of acquired resistance genes, including carbapenemases. Whole-genome sequencing was performed using Illumina sequencing technology. Susceptibly was determined using the broth microdilution method. In the entire sample, 43.5% were high-risk clones. A main clade (27.1% of isolates) found in multiple hospitals comprised 19 isolates belonging to the high-risk ST654 clone and four closely related isolates. The isolates in this m

SUBMITTER: Kon H 

PROVIDER: S-EPMC11619238 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature