The host cells suppress the proliferation of pseudorabies virus by regulating the PI3K/Akt/mTOR pathway.

ABSTRACT: Pseudorabies virus (PRV), a member of the alpha-herpesviruses, can infect both the nervous and reproductive systems of pigs, causing neonatal mortality and reproductive failure in sows, which incurs substantial economic losses. Neurotropism is a common characteristic of various viruses, allowing them to cross the blood-brain barrier and access the central nervous system. However, the precise mechanisms by which PRV affects the blood-brain barrier are not well understood. To investigate the mechanism of PRV's interaction with the blood-brain barrier and its engagement with the PI3K/Akt signaling pathway during infection, an in vitro monolayer cell model of the blood-brain barrier was established. Our research found that PRV activates Matrix metallopeptidase 2 (MMP2), which degrades Z

SUBMITTER: Xu L 

PROVIDER: S-EPMC11619243 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature