Insights into respiratory microbiome composition and systemic inflammatory biomarkers of bronchiectasis patients.

ABSTRACT: The human microbiomes, including the ones present in the respiratory tract, are described and characterized in an increasing number of studies. However, the composition and the impact of the healthy and/or impaired microbiome on pulmonary health and its interaction with the host tissues remain enigmatic. In chronic airway diseases, bronchiectasis stands out as a progressive condition characterized by microbial colonization and infection. In this study, we aimed to investigate the microbiome of the lower airways and lungs of bronchiectasis patients together with their serum cytokine and chemokine content, and gain novel insights into the pathogenesis of bronchiectasis. The microbiome of 47 patients was analyzed by sequencing of full-length 16S rRNA gene using amplicon sequencing Oxford Nano

SUBMITTER: Konovalovas A 

PROVIDER: S-EPMC11619244 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature