Elevated whole blood viscosity is associated with an impaired insulin-stimulated myocardial glucose metabolism.

ABSTRACT:

Background

Increased whole blood viscosity (WBV) was associated with impaired peripheral glucose metabolism, type 2 diabetes, and cardiovascular disease (CVD). Impaired myocardial glucose metabolism is a risk factor for CVD. Whether an increased WBV is associated with impaired myocardial glucose metabolism is still undefined.

Methods

To elucidate this issue, we evaluated the association between WBV and myocardial glucose metabolic rate (MRGlu) in 57 individuals with different glucose tolerance status. Myocardial MRGlu was assessed using dynamic cardiac ¹⁸F-FDG PET combined with euglycemic hyperinsulinemic clamp. WBV was calculated using a validated equation including hematocrit and plasma proteins: WBV = [0.12 × h] + [0.17 × (p - 2.07)], where h is the hematocrit

SUBMITTER: Succurro E 

PROVIDER: S-EPMC11619250 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature