Pullulan nanoparticles inhibit the pathogenicity of <i>Candida albicans</i> by regulating hypha-related gene expression.

ABSTRACT: Candida albicans is a prevalent opportunistic pathogenic fungus that resides in the skin and gastrointestinal (GI) tract of humans. Under specific conditions, C. albicans cells transition from a commensal to a pathogenic state, leading to both superficial and invasive infections. Although systemic candidiasis poses a life-threatening risk, a limited number of antifungal drugs are employed for its treatment. Moreover, the emergence of resistant strains to antifungal agents underscores the pressing need for new treatment options. In this study, we propose the use of polysaccharide nanoparticles as a strategy for treating candidiasis. We synthesized phthalic pullulan nanoparticles (PPNPs) and examined their ability to inhibit the pathogenicity of C. albicans. We observed

SUBMITTER: Hong S 

PROVIDER: S-EPMC11619324 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature