Ruthenaelectro-catalyzed C-H phosphorylation: ortho to para position-selectivity switch.

ABSTRACT: The position-selective C-H bond activation of arenes has long been a challenging topic. Herein, we report an expedient ruthenium-electrocatalyzed site-selective ortho-C-H phosphorylation of arenes driven by electrochemical hydrogen evolution reaction (HER), avoiding stoichiometric amounts of chemical redox-waste products. This strategy paved the way to achieve unprecedented ruthenaelectro-catalyzed para-C-H phosphorylation with excellent levels of site-selectivity. This electrocatalytic approach was characterized by an ample substrate scope with a broad range of arenes containing N-heterocycles, as well as several aryl/alkylphosphine oxides were well tolerated. Moreover, late-stage C-H phosphorylation of medicinal relevant drugs could also be achieved. DFT mechanistic studies

SUBMITTER: Gou XY 

PROVIDER: S-EPMC11619359 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature