Interspecies interactions alter the antibiotic sensitivity of <i>Pseudomonas aeruginosa</i>.

ABSTRACT: Polymicrobial infections are infections that are caused by multiple pathogens and are common in patients with cystic fibrosis (CF). Although polymicrobial infections are associated with poor treatment responses in CF, the effects of the ecological interactions between co-infecting pathogens on antibiotic sensitivity and treatment outcome are poorly characterized. To this end, we systematically quantified the impact of these effects on the antibiotic sensitivity of Pseudomonas aeruginosa for nine antibiotics in medium conditioned by 13 secondary cystic fibrosis-associated bacterial and fungal pathogens through time-kill assays. We fitted pharmacodynamic models to these kill curves for each antibiotic-species combination and found that interspecies interactions changing the antibiotic

SUBMITTER: Koumans CIM 

PROVIDER: S-EPMC11619387 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature