Evaluation of ALKBH2 and ALKBH3 gene regulation in patients with adult T-cell leukemia/lymphoma.

ABSTRACT:

Background

Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic virus that causes malignant adult T-cell leukemia/lymphoma (ATL). Patients infected with HTLV-1 are considered HTLV-1 carriers, and a small proportion of patients progress to life-threatening ATL after a long asymptomatic phase. No antiviral agent or preventive vaccine specific for HTLV-1 infection is established in current situation. For development of countermeasures to combat HTLV-1 infection and ATL, it is essential to expand our knowledge about their pathogenesis. Recently, AlkB homolog (ALKBH) family have been shown to participate in the oncogenesis of various cancer types.

Methods

To investigate the potential role of ALKBH family members in the pathogenesis of ATL, we analyzed their gene expression

SUBMITTER: Wada Y 

PROVIDER: S-EPMC11619432 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature