Alterations of gut microbiota and metabolome are associated with primary nephrotic syndrome in children.

ABSTRACT:

Background

Primary nephrotic syndrome (PNS) is a common glomerular disease in children. Dysbiosis of gut microbiota acts as a cause of Treg abnormalities. However, the intestinal metabolic impact of PNS with children remains poorly understood. This study aims to investigate the dynamic changes of gut microbiota and it's metabolism in children with PNS.

Methods

Fecal and peripheral blood samples were separately collected from patients with initial diagnosis of PNS (PNS_In group), recurrence of PNS (PNS_Re group), and healthy controls (HCs group). The fecal samples were subjected to the microbiome and metabolome by the multi-omics analysis. Additionally, the peripheral blood samples were collected and associated inflammatory indicators were determined.

Results

We found

SUBMITTER: Ma X 

PROVIDER: S-EPMC11619441 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature