Distinct impacts of each anti-anti-sigma factor ortholog of the chlamydial Rsb partner switching mechanism on development in Chlamydia trachomatis.

ABSTRACT: Partner switching mechanisms (PSMs) are signal transduction systems comprised of a sensor phosphatase (RsbU), an anti-sigma factor (RsbW, kinase), an anti-anti-sigma factor (RsbV, the RsbW substrate), and a target sigma factor. Chlamydia spp. are obligate intracellular bacterial pathogens of animals that undergo a developmental cycle transitioning between the infectious elementary body (EB) and replicative reticulate body (RB) within a host cell-derived vacuole (inclusion). Secondary differentiation events (RB to EB) are transcriptionally regulated, in part, by the housekeeping sigma factor (σ⁶⁶) and two late-gene sigma factors (σ⁵⁴ and σ²⁸). Prior research supports that the PSM in Chlamydia trachomatis regulates availability of σ⁶⁶

SUBMITTER: Junker S 

PROVIDER: S-EPMC11619594 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature