High rate of macrolide resistance and closely genetically related <i>Mycobacterium abscessus</i> complex strains identified among both cystic fibrosis and non-cystic fibrosis patients within two countries.

ABSTRACT: Mycobacterium abscessus is an emerging opportunistic pathogen affecting patients with chronic lung diseases, primarily cystic fibrosis (CF), or those under immunosuppression. Hence, investigations into the epidemiology and transmission of M. abscessus and accurate antibiotic susceptibility data are essential for the effective treatment of infections caused by this pathogen. This retrospective nationwide study included all clinical M. abscessus isolates (n = 59) from 29 patients diagnosed in the Czech Republic and Slovakia between 2018 and 2023. Whole genome sequencing (WGS) was performed to identify clusters and classify isolates into predominant circulating clones (DCC). Subspecies identification of unique isolates showed subspecies abscessus as the most

SUBMITTER: Dohal M 

PROVIDER: S-EPMC11619595 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature