ApoC-III proteoforms are associated with better lipid, inflammatory, and glucose profiles independent of total apoC-III.

ABSTRACT:

Background

Apolipoprotein (apo) C-III is involved in several processes that increase triglyceride levels, inflammation, and insulin resistance. Four of its proteoforms have been the focus of several studies and have shown differential associations with cardiovascular risk biomarkers, mostly lipids. However, there are other proteoforms of apoC-III that have not yet been investigated in detail. The aim of this study was to evaluate the associations of seven apoC-III proteoforms with a comprehensive set of biomarkers, including lipid metabolism, inflammation, and glucose homeostasis.

Methods

Seven apoC-III proteoforms (apoC-III_0a, apoC-III_0b, apoC-III₁, apoC-III_1d, apoC-III₂, apoC-III_2d, and apoC-III_0f

SUBMITTER: Rehues P 

PROVIDER: S-EPMC11619673 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature