A cross-sectional study of associations between the ¹³C-sucrose breath test, the lactulose rhamnose assay, and growth in children at high risk of environmental enteropathy.

ABSTRACT:

Background

Environmental enteropathy' (EE) is common among children who are highly exposed to enteric pathogens in low-resource settings. We optimized and validated a stable isotope-based breath test of intestinal sucrase activity (¹³C-SBT) as a noninvasive test of carbohydrate digestion and metabolism.

Objectives

The primary objective of this study was to assess the relationship between the ¹³C-SBT and the lactulose/rhamnose ratio (LR) and growth in children. Secondary objectives were to assess the relationship between the ¹³C-SBT and additional biomarkers of EE. We also characterized the relationship between the ¹³C-SBT and child sex and dietary diversity, as well as household socio-economic status and food security.

Methods</

SUBMITTER: Shivakumar N 

PROVIDER: S-EPMC11619784 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature