Relationship between EZH2 expression and prognosis of patients with hepatocellular carcinoma using a pathomics predictive model.

ABSTRACT:

Background

Enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) is overexpressed in hepatocellular carcinoma, promoting tumorigenesis and correlating with poor prognosis. Traditional histopathological examinations are insufficient to accurately predict hepatocellular carcinoma (HCC) survival; however, pathomics models can predict EZH2 expression and HCC prognosis. This study aimed to investigate the relationship between pathomics features and EZH2 expression for predicting overall survival of patients with HCC.

Methods

We analyzed 267 patients with HCC from the Cancer Genome Atlas database, with available pathological images and gene expression data. RNA sequencing data were divided into high and low EZH2 expression groups for prognosis and survival analysis. Pat

SUBMITTER: Zhou X 

PROVIDER: S-EPMC11619983 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature