Burden of illness of non-hematopoietic stem cell transplant-related hepatic sinusoidal obstruction syndrome: A systematic review.

ABSTRACT:

Background

Sinusoidal obstruction syndrome (SOS)/veno-occlusive disease (VOD) is generally associated with hematopoietic cell transplant (HCT), but little is known about this condition outside the HCT setting. This systematic review examines the burden of illness and current management approaches in non-HCT SOS/VOD.

Methods

We searched Embase, Medline, and grey literature sources for non-HCT SOS/VOD studies published 2002-2023. Inclusion criteria were studies of any design reporting incidence, diagnosis, underlying disease and any ongoing treatment at the time of SOS/VOD onset, management of non-HCT SOS/VOD, clinical burden, health-related quality of life, healthcare resource use, costs, and patients' unmet needs. Studies investigating pulmonary VOD or SOS/VOD related to the

SUBMITTER: Fan L 

PROVIDER: S-EPMC11619986 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature