Endoscopic brush sampling identifies mucosa associated microbiota in colorectal adenomas.

ABSTRACT: The intestinal microbiome plays a crucial role in colorectal adenomas and the mucosa associated microbiota are thought to play a more critical role in interactions with the host immune system. Current omics approaches, offer a holistic assessment of the gut microbiome and the human host interaction. To enhance the value of data from these sequencing methods, appropriate sample collection is vital. We evaluated the potential use of endoscopic brush samples for mucosal microbiota analysis in colorectal adenomas and compared it with direct adenoma tissue sequencing in terms of microbial gene sequencing. The results showed a significant increase in microbial diversity in samples collected by the endoscopic brush, which did not interfere with pathological biopsy. This study found that utilizing

SUBMITTER: Liu J 

PROVIDER: S-EPMC11620161 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature