Chemical characterization, neuroprotective effect, and in-silico evaluation of the petroleum ether extract of three palm tree species against glutamate-induced excitotoxicity in rats.

ABSTRACT: The burden of neurological disorders is growing substantially with limited therapeutic options, urging the consideration and assessment of alternative strategies. In this regard, we aimed to elucidate the phytochemical profile of the petroleum ether extract (PEE) of three palm tree species: Aiphanes eggersii Burret, Carpoxylon macrospermum H. Wendl. & Drude, and Jubaeopsis caffra Becc. (Family Arecaceae), and to evaluate their neuroprotective effect in monosodium glutamate (MSG)-induced excitotoxicity model for the first time. We identified a total of 48, 18, and 45 compounds in A. eggersii, C. macrospermum, and J. caffra, constituting 79.41 %, 60.45 %, and 76.35 % of the total detected compounds, respectively. A. eggersii extract was rich i

SUBMITTER: Moharram FA 

PROVIDER: S-EPMC11620252 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature