Revisiting the functional annotation of TriTryp using sequence similarity tools.

ABSTRACT: Trypanosomatids are the causative agents of deadly diseases in humans and livestock. Given the high phylogenetic distance of trypanosomatids from model organisms, these organisms have ample unannotated genes. Manual functional annotation is time-consuming, highlighting the importance of automated functional annotation tools. The development of automated functional tools is a hot research topic, and multiple tools have been developed for the task. PANNZER2 is an automated functional annotation tool that merely relies on the sequence similarity of the query to the annotated proteins. We tried PANNZER2 on Trypanosoma brucei, the most studied organism among trypanosomatids, to see if it could improve our knowledge of the functions of the genes. Even with the availability of automated an

SUBMITTER: Borujeni PM 

PROVIDER: S-EPMC11620254 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature