Rare but elevated incidence of hematological malignancy after clozapine use in schizophrenia: A population cohort study.

ABSTRACT:

Background

Clozapine is widely regarded as a highly efficacious psychotropic drug that is largely underused worldwide. Recent disproportionality analyses and nationwide case-control studies suggested a potential association between clozapine use and hematological malignancy (HM). Nevertheless, the absolute rate difference is not well-established due to the absence of analytic cohort studies. The clinical significance of such a potential risk remains unclear.

Methods and findings

We extracted data from a territory-wide public healthcare database from January 2001 to August 2022 in Hong Kong to conduct a retrospective cohort study of anonymized patients aged 18+ years with a diagnosis of schizophrenia who used clozapine or olanzapine (drug comparator with highly similar chemic

SUBMITTER: Hu Y 

PROVIDER: S-EPMC11620352 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature