Copy number variants underlie major selective sweeps in insecticide resistance genes in Anopheles arabiensis.

ABSTRACT: To keep ahead of the evolution of resistance to insecticides in mosquitoes, national malaria control programmes must make use of a range of insecticides, both old and new, while monitoring resistance mechanisms. The outdoor-biting malaria vector Anopheles arabiensis is of increasing concern for malaria transmission because it is apparently less susceptible to many indoor control interventions, yet knowledge of its mechanisms of resistance remains limited. Furthermore, comparatively little is known in general about resistance to non-pyrethroid insecticides such as pirimiphos-methyl (PM), which are crucial for effective control in the context of globally high resistance to pyrethroids. We performed a genome-wide association study to determine the molecular mechanisms of resistance to the pyr

SUBMITTER: Lucas ER 

PROVIDER: S-EPMC11620391 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature