Modelling the effectiveness of antiviral treatment strategies to prevent household transmission of acute respiratory viruses.

ABSTRACT: Households are a major driver of transmission of acute respiratory viruses, such as SARS-CoV-2 or Influenza. Until now antiviral treatments have mostly been used as a curative treatment in symptomatic individuals. During an outbreak, more aggressive strategies involving pre- or post-exposure prophylaxis (PrEP or PEP) could be employed to further reduce the risk of severe disease but also prevent transmission to household contacts. In order to understand the effectiveness of such strategies and the factors that may modulate them, we developed a multi-scale model that follows the infection at both the individual-level (viral dynamics) and the population-level (transmission dynamics) in households. Using a simulation study we explored different antiviral treatment strategies, evaluating their

SUBMITTER: Zaaraoui H 

PROVIDER: S-EPMC11620401 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature