Genetic variants associated with sepsis-associated acute kidney injury.

ABSTRACT:

Background

Kidney dysfunction is a common complication in septic patients. Studies have identified numerous risk factors for sepsis-associated acute kidney injury (S-AKI), yet there is wide variability in the incidence even among patients with similar risk factors, suggesting the presence of additional uncharacterized risk factors, including genetic differences. The expansion of biobanks, advances in genotyping, and standardized diagnostic criteria have enabled large-scale, hypothesis-generating studies into the genetic mechanisms underlying S-AKI. We hypothesize that the genetic pathway behind S-AKI has overlapping mechanisms with key differences based upon the specific subtype of acute kidney injury (AKI).

Methods

To test this hypothesis, we performed a genome-wide associa

SUBMITTER: Douville NJ 

PROVIDER: S-EPMC11620412 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature