Understanding tuberculosis transmission and progression: A prospective cohort study of index cases and close contacts in Moldova.

ABSTRACT:

Objectives

This study aims to determine the progression rate, risk factors and timeline for the progression from exposure to active tuberculosis (TB) in a high-risk population. Using a prospective cohort in the Republic of Moldova, we investigated pulmonary TB disease progression among close contacts of patients with TB in a low-burden country with high rates of drug-resistant TB.

Methods

Close contacts of patients with newly diagnosed TB were recruited and monitored to evaluate for progression rates to active TB. Data collected included demographic information, medical and exposure history, and clinical samples. Follow-up clinical evaluations of close contacts were conducted at regular intervals over at least 24 months to monitor for progression to TB disease.

Results

SUBMITTER: Syed RR 

PROVIDER: S-EPMC11620447 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature