Superhydrophilic Fluorinated Polymer Probe for Zero-Background ¹⁹F MRI with Adaptable Targeting Ability.

ABSTRACT: ¹⁹F magnetic resonance imaging (¹⁹F MRI), with zero background, high tissue penetration depth, excellent spatial resolution, and nonradioactive features, has attracted considerable attention but faces tough challenges due to the shortage of sensitive and selective targetable probes. Herein, we report a biocompatible and highly sensitive ¹⁹F MRI probe with an adaptable tumor-targeting ability. The fluorine-grafted polymer (PIBMA-F_SON) probes were rich with sulfoxide and carboxy groups, containing a high fluorine content (∼17 wt %). The probes exhibit superhydrophilicity, strong ¹⁹F MRI signals (enhancement of ∼95-fold), long transverse relaxation time (T₂, 422 ms), and excellent ¹⁹F MRI capability. Conjugati

SUBMITTER: Guo C 

PROVIDER: S-EPMC11620481 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature