Inactivation of the ribosome assembly factor RimP causes streptomycin resistance and impairs motility in <i>Salmonella</i>.

ABSTRACT: The ribosome is the central hub for protein synthesis and the target of many antibiotics. Although the majority of ribosome-targeting antibiotics inhibit protein synthesis and are bacteriostatic, aminoglycosides promote protein mistranslation and are bactericidal. Understanding the resistance mechanisms of bacteria against aminoglycosides is not only vital for improving the efficacy of this critically important group of antibiotics but also crucial for studying the molecular basis of translational fidelity. In this work, we analyzed Salmonella mutants evolved in the presence of the aminoglycoside streptomycin (Str) and identified a novel gene rimP to be involved in Str resistance. RimP is a ribosome assembly factor critical for the maturation of the 30S small subunit that bin

SUBMITTER: Lyu Z 

PROVIDER: S-EPMC11620500 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature