Altered serine metabolism promotes drug tolerance in <i>Mycobacterium abscessus</i> via a WhiB7-mediated adaptive stress response.

ABSTRACT: Mycobacterium abscessus is an emerging opportunistic pathogen responsible for chronic lung diseases, especially in patients with cystic fibrosis. Treatment failure of M. abscessus infections is primarily associated with intrinsic or acquired antibiotic resistance. However, there is growing evidence that antibiotic tolerance, i.e., the ability of bacteria to transiently survive exposure to bactericidal antibiotics through physiological adaptations, contributes to the relapse of chronic infections and the emergence of acquired drug resistance. Yet, our understanding of the molecular mechanisms that underlie antibiotic tolerance in M. abscessus remains limited. In the present work, a mutant with increased cross-tolerance to the first- and second-line antibiotics cefoxitin

SUBMITTER: Bernard C 

PROVIDER: S-EPMC11620514 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature