Catalytic functionalization of unactivated primary C-H bonds directed by an alcohol.

ABSTRACT: New synthetic methods for the catalytic functionalization of C-H bonds have the potential to revolutionize the synthesis of complex molecules. However, the realization of this synthetic potential requires the ability to functionalize selectively one C-H bond in a compound containing many such bonds and an array of functional groups. The site-selective functionalization of aliphatic C-H bonds is one of the greatest challenges that must be met for C-H bond functionalization to be used widely in complex-molecule synthesis, and processes catalysed by transition-metals provide the opportunity to control selectivity. Current methods for catalytic, aliphatic C-H bond functionalization typically rely on the presence of one inherently reactive C-H bond, or on installation and subsequent removal of

SUBMITTER: Simmons EM 

PROVIDER: S-EPMC11620535 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature