External negative pressure transiently reduces intravenous pressure and augments the arteriovenous pressure gradient in the affected limb segment.

ABSTRACT: Recently intermittent negative pressure has emerged as a potential treatment in vascular disease and has similarities with established experimental interventions such as lower body negative pressure. The direct, local influences of either method upon intravascular pressure still require some clarification however, particularly in the immediate moments following onset. We investigated the acute intravascular pressure responses to intermittent cycles of negative pressure in the supine and sitting postures. Fifteen participants (6 female) received intermittent negative pressure cycles (-37 mmHg; 9.5-sec on, 7.5-sec off) upon the lower leg in both postures. Saphenous venous (n = 15), and dorsalis pedis artery pressure (n = 3) were recorded via pressure catheter, alongside beat-by-beat systemic

SUBMITTER: Callender NA 

PROVIDER: S-EPMC11620561 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature