Turnover of retroelements and satellite DNA drives centromere reorganization over short evolutionary timescales in Drosophila.

ABSTRACT: Centromeres reside in rapidly evolving, repeat-rich genomic regions, despite their essential function in chromosome segregation. Across organisms, centromeres are rich in selfish genetic elements such as transposable elements and satellite DNAs that can bias their transmission through meiosis. However, these elements still need to cooperate at some level and contribute to, or avoid interfering with, centromere function. To gain insight into the balance between conflict and cooperation at centromeric DNA, we take advantage of the close evolutionary relationships within the Drosophila simulans clade-D. simulans, D. sechellia, and D. mauritiana-and their relative, D. melanogaster. Using chromatin profiling combined with high-resolution fluorescence in situ hybridization on stretched chromatin

SUBMITTER: Courret C 

PROVIDER: S-EPMC11620609 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature