Species-specific renal and liver responses during infection with food-borne trematodes Opisthorchis felineus, Opisthorchis viverrini, or Clonorchis sinensis.

ABSTRACT: Three food-borne trematodes-Opisthorchis felineus, Opisthorchis viverrini, and Clonorchis sinensis-are closely related epidemiologically important species. Despite the similarity of their life cycles, these liver flukes also have marked differences in the geographical range, helminth biology, and hepatobiliary disorders. O. viverrini and C. sinensis are classified as Group 1 biological carcinogens while O. felineus is not. Direct comparisons of systemic response to the liver fluke infections are unexplored aspects. This study was carried out to identify species-specific liver and kidney responses in the hamster models after the infection with one of the three liver flukes. Liver periductal-fibrosis development was similar between hamsters infected with O. felineus or C. sinensis, whereas b

SUBMITTER: Zaparina OG 

PROVIDER: S-EPMC11620611 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature