RT-Sort: An action potential propagation-based algorithm for real time spike detection and sorting with millisecond latencies.

ABSTRACT: With the use of high-density multi-electrode recording devices, electrophysiological signals resulting from action potentials of individual neurons can now be reliably detected on multiple adjacent recording electrodes. Spike sorting assigns these signals to putative neural sources. However, until now, spike sorting can only be performed after completion of the recording, preventing true real time usage of spike sorting algorithms. Utilizing the unique propagation patterns of action potentials along axons detected as high-fidelity sequential activations on adjacent electrodes, together with a convolutional neural network-based spike detection algorithm, we introduce RT-Sort (Real Time Sorting), a spike sorting algorithm that enables the sorted detection of action potentials within 7.5ms±1.

SUBMITTER: van der Molen T 

PROVIDER: S-EPMC11620616 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature