Spatiotemporal patterns of gene expression during development of a complex colony morphology.

ABSTRACT: Clonal communities of single celled organisms, such as bacterial or fungal colonies and biofilms, are spatially structured, with subdomains of cells experiencing differing environmental conditions. In the development of such communities, cell specialization is not only important to respond and adapt to the local environment but has the potential to increase the fitness of the clonal community through division of labor. Here, we examine colony development in a yeast strain (F13) that produces colonies with a highly structured "ruffled" phenotype in the colony periphery and an unstructured "smooth" phenotype in the colony center. We demonstrate that in the F13 genetic background deletions of transcription factors can either increase (dig1D, sfl1D) or decrease (tec1D) the degree of colony str

SUBMITTER: Cromie GA 

PROVIDER: S-EPMC11620645 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature