Reductive Elimination from Phosphine-Ligated Alkylpalladium(II) Amido Complexes To Form sp³ Carbon-Nitrogen Bonds.

ABSTRACT: We report the formation of phosphine-ligated alkylpalladium(II) amido complexes that undergo reductive elimination to form alkyl-nitrogen bonds and a combined experimental and computational investigation of the factors controlling the rates of these reactions. The free-energy barriers to reductive elimination from t-Bu₃P-ligated complexes were significantly lower (ca. 3 kcal/mol) than those previously reported from NHC-ligated complexes. The rates of reactions from complexes containing a series of electronically and sterically varied anilido ligands showed that the reductive elimination is slower from complexes of less electron-rich or more sterically hindered anilido ligands than from those containing more electron-rich and less hindered anilido ligands. Reductive elimination o

SUBMITTER: Peacock DM 

PROVIDER: S-EPMC11620734 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature