Spinal neural tube formation and tail development in human embryos.

ABSTRACT: Primary and secondary neurulation - processes that form the spinal cord - are incompletely understood in humans, largely due to the challenge of accessing neurulation-stage embryos (3-7 weeks post-conception). Here, we describe findings from 108 human embryos, spanning Carnegie stages (CS) 10-18. Primary neurulation is completed at the posterior neuropore with neural plate bending that is similar, but not identical, to the mouse. Secondary neurulation proceeds from CS13 with formation of a single lumen as in mouse, not coalescence of multiple lumens as in chick. There is no evidence of a 'transition zone' from primary to secondary neurulation. Secondary neural tube 'splitting' occurs in 60% of proximal human tail regions. A somite is formed every 7 hr in human, compared with 2 hr in mice a

SUBMITTER: Santos C 

PROVIDER: S-EPMC11620743 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature