A novel monomeric amyloid β-activated signaling pathway regulates brain development via inhibition of microglia.

ABSTRACT: Amyloid β (Aβ) forms aggregates in the Alzheimer's disease brain and is well known for its pathological roles. Recent studies show that it also regulates neuronal physiology in the healthy brain. Whether Aβ also regulates glial physiology in the normal brain, however, has remained unclear. In this article, we describe the discovery of a novel signaling pathway activated by the monomeric form of Aβ in vitro that plays essential roles in the regulation of microglial activity and the assembly of neocortex during mouse development in vivo. We find that activation of this pathway depends on the function of amyloid precursor and the heterotrimeric G protein regulator Ric8a in microglia and inhibits microglial immune activation at transcriptional and post-transcriptional levels. Genetic disruptio

SUBMITTER: Kwon HJ 

PROVIDER: S-EPMC11620749 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature